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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Main article: Heart development
The heart of mammals develops from the embryonic mesoderm that differentiated into the mesothelium, endothelium, and myocardium after gastrulation. The pericardium of the middle art forms the inner lining of the heart. The outer covering of the heart, lymph, and blood vessels develop from the endothelium. The cardiovascular or myocardium develops in the heart muscle.                                                                                                                                                                                                                                     

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